Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner

Supachoke Mangmool, Tananat Denkaew, Sarawuth Phosri, Darawan Pinthong, Warisara Parichatikanond, Tsukasa Shimauchi, Motohiro Nishida

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抄録

Insulin resistance is a condition in which cells are defective in response to the actions of insulin in tissue glucose uptake. Overstimulation of β-adrenergic receptors (βARs) leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, the mechanisms by which sustained βAR stimulation affects insulin resistance in the heart are incompletely understood. In this study, we demonstrate that sustained βAR stimulation resulted in the inhibition of insulin-induced glucose uptake, and a reduction of insulin induced glucose transporter (GLUT)4 expression that were mediated by the β2AR subtype in cardiomyocytes and heart tissue. Overstimulation of β2AR inhibited the insulin-induced translocation of GLUT4 to the plasma membrane of cardiomyocytes. Additionally, βAR mediated cardiac insulin resistance by reducing glucose uptake and GLUT4 expression via the cAMP-dependent and protein kinase A-dependent pathways. Treatment with β-blockers, including propranolol and metoprolol antagonized isoproterenol-mediated insulin resistance in the heart. The data in this present study confirm a critical role for protein kinase A in βAR-mediated insulin resistance.

元の言語英語
ページ(範囲)118-132
ページ数15
ジャーナルMolecular Endocrinology
30
発行部数1
DOI
出版物ステータス出版済み - 1 1 2016

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Adrenergic Receptors
Insulin Resistance
Cyclic AMP-Dependent Protein Kinases
Insulin
Cardiac Myocytes
Glucose
Metoprolol
Facilitative Glucose Transport Proteins
Isoproterenol
Propranolol
Heart Failure
Cell Membrane

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Endocrinology

これを引用

Mangmool, S., Denkaew, T., Phosri, S., Pinthong, D., Parichatikanond, W., Shimauchi, T., & Nishida, M. (2016). Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner. Molecular Endocrinology, 30(1), 118-132. https://doi.org/10.1210/me.2015-1201

Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner. / Mangmool, Supachoke; Denkaew, Tananat; Phosri, Sarawuth; Pinthong, Darawan; Parichatikanond, Warisara; Shimauchi, Tsukasa; Nishida, Motohiro.

:: Molecular Endocrinology, 巻 30, 番号 1, 01.01.2016, p. 118-132.

研究成果: ジャーナルへの寄稿記事

Mangmool, S, Denkaew, T, Phosri, S, Pinthong, D, Parichatikanond, W, Shimauchi, T & Nishida, M 2016, 'Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner', Molecular Endocrinology, 巻. 30, 番号 1, pp. 118-132. https://doi.org/10.1210/me.2015-1201
Mangmool S, Denkaew T, Phosri S, Pinthong D, Parichatikanond W, Shimauchi T その他. Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner. Molecular Endocrinology. 2016 1 1;30(1):118-132. https://doi.org/10.1210/me.2015-1201
Mangmool, Supachoke ; Denkaew, Tananat ; Phosri, Sarawuth ; Pinthong, Darawan ; Parichatikanond, Warisara ; Shimauchi, Tsukasa ; Nishida, Motohiro. / Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner. :: Molecular Endocrinology. 2016 ; 巻 30, 番号 1. pp. 118-132.
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