Sympathoinhibition caused by orally administered telmisartan through inhibition of the at 1 receptor in the rostral ventrolateral medulla of hypertensive rats

Takuya Kishi, Yoshitaka Hirooka, Kenji Sunagawa

    研究成果: Contribution to journalArticle査読

    31 被引用数 (Scopus)

    抄録

    In patients and animals with hypertension, sympathetic nervous system (SNS) activation is present. We have demonstrated that angiotensin II type 1 receptor (AT 1 R)-induced oxidative stress in the rostral ventrolateral medulla (RVLM), a vasomotor center in the brainstem, causes SNS activation in hypertensive rats. The aim of the present study was to determine whether orally administered AT 1 R blockers (ARBs) inhibit SNS activation through an anti-oxidant effect via inhibition of AT 1 R in the RVLM of hypertensive rats and, if so, whether the benefits are class effects of ARBs. Stroke-prone spontaneously hypertensive rats (SHRSPs), a hypertensive model with sympathoexcitation, were divided into four groups: SHRSPs treated with telmisartan (TLM), candesartan (CAN), or hydralazine (HYD) and a vehicle group (VEH). Although systolic blood pressure was reduced in the TLM, CAN and HYD groups to the same level, heart rate, SNS activation and oxidative stress in the RVLM were significantly lower in the TLM group only. The pressor effect caused by the microinjection of angiotensin II into the RVLM and the depressor effect caused by the microinjection of tempol, a superoxide dismutase mimetic, into the RVLM were both significantly smaller in TLM, but not in CAN or HYD. These results suggest that orally administered TLM inhibits SNS activation through an anti-oxidant effect via inhibition of AT 1 R in the RVLM of SHRSPs; these results are also independent of depressor effects and are not class effects of ARBs.

    本文言語英語
    ページ(範囲)940-946
    ページ数7
    ジャーナルHypertension Research
    35
    9
    DOI
    出版ステータス出版済み - 9 2012

    All Science Journal Classification (ASJC) codes

    • Internal Medicine
    • Physiology
    • Cardiology and Cardiovascular Medicine

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