Synaptic plasticity and synaptic reorganization regulated by microglia

Yoshinori Hayashi, Hiroshi Nakanishi

研究成果: ジャーナルへの寄稿評論記事

2 引用 (Scopus)

抄録

Microglia are generally believed to be brain macrophages, which become phagocytic cells after cellular activation in response to inflammation or injury in the brain. However, accumulating evidence suggests that microglia modulate neurotransmission and synaptic plasticity by secretion of several soluble factors. Importantly, microglia secret glycine to enhance NMDA receptor-mediated responses and hippocampal long-term potentiation, a cellular basis of learning and memory. Although the expression of NMDA receptors was also observed in microglia, NMDA receptor-mediated responses were not induced in microglia. This suggests that NMDA receptors expressed in microglia are not functional. Besides the modulation of synaptic transmission, microglia also play an important role in synaptic remodeling by the pruning of unnecessary synapses and axon terminals during the postnatal developmental stage and adaptation to novel environments even in the healthy brain. Furthermore, we have recently found that clock genes in microglia drive P2Y12R and cathepsin S to regulate diurnal change in the synaptic activity. Therefore, defects in these microglial functions may eventually result in several brain diseases including neuropsychiatric disorders.

元の言語英語
ページ(範囲)211-216
ページ数6
ジャーナルJapanese Journal of Neuropsychopharmacology
33
発行部数5-6
出版物ステータス出版済み - 11 2013

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Neuronal Plasticity
Microglia
N-Methyl-D-Aspartate Receptors
cathepsin S
Synaptic Transmission
Long-Term Potentiation
Presynaptic Terminals
Brain
Brain Diseases
Phagocytes
Synapses
Glycine
Brain Injuries
Macrophages
Learning
Inflammation

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Clinical Psychology
  • Pharmacology (medical)
  • Pharmacology

これを引用

Synaptic plasticity and synaptic reorganization regulated by microglia. / Hayashi, Yoshinori; Nakanishi, Hiroshi.

:: Japanese Journal of Neuropsychopharmacology, 巻 33, 番号 5-6, 11.2013, p. 211-216.

研究成果: ジャーナルへの寄稿評論記事

Hayashi, Yoshinori ; Nakanishi, Hiroshi. / Synaptic plasticity and synaptic reorganization regulated by microglia. :: Japanese Journal of Neuropsychopharmacology. 2013 ; 巻 33, 番号 5-6. pp. 211-216.
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