Syntheses and functions of Glycosaminoglycan mimicking polymers

Yoshiko Miura, Tomohiro Fukuda, Hirokazu Seto, Yu Hoshino

研究成果: 著書/レポートタイプへの貢献

抄録

Glycosaminoglycans (GAGs) are important polysaccharides in the living system. Though total syntheses of GAGs oligosaccharides have been reported, it is still difficult to obtain GAGs. In this investigation, GAGs mimetics were prepared by polymerization of vinyl sugars instead of total synthesis. Glycopolymers are polymers with pendant saccharides, and exhibit a strong molecular recognition due to the multivalency. GAGs mimicking glycopolymers were prepared by polymerizing acrylamide derivatives carrying sulfated N-acetyl glucosamine (GlcNAc). The polymer interactions with proteins were investigated. The glycopolymer libraries were prepared with varying molecular weight, sugar structure, and sugar ratios. The GAG glycopolymers with biodegradable backbone, dendrimer, and arrays were also prepared. The inhibitory activity of Alzheimer amyloid beta peptides by the glycopolymers was investigated in detail. The glycopolymer with sulfated GlcNAc inhibited the aggregation of amyloid beta (Aβ) and the multivalency of sulfated GlcNAc was the key of the interaction. The activity depends on the chemical structure of glycopolymers. Also, the sulfated saccharide function was correlated to the functions of native GAGs.

元の言語英語
ホスト出版物のタイトルCoupling and Decoupling of Diverse Molecular Units in Glycosciences
出版者Springer International Publishing
ページ213-224
ページ数12
ISBN(電子版)9783319655871
ISBN(印刷物)9783319655864
DOI
出版物ステータス出版済み - 11 20 2017

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Glycosaminoglycans
Polymers
Sugars
Glucosamine
Dendrimers
Molecular recognition
Oligosaccharides
Acrylamide
Amyloid beta-Peptides
Polysaccharides
Amyloid
Peptides
Agglomeration
Molecular weight
Polymerization
Derivatives
Proteins

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Engineering(all)
  • Materials Science(all)

これを引用

Miura, Y., Fukuda, T., Seto, H., & Hoshino, Y. (2017). Syntheses and functions of Glycosaminoglycan mimicking polymers. : Coupling and Decoupling of Diverse Molecular Units in Glycosciences (pp. 213-224). Springer International Publishing. https://doi.org/10.1007/978-3-319-65587-1_10

Syntheses and functions of Glycosaminoglycan mimicking polymers. / Miura, Yoshiko; Fukuda, Tomohiro; Seto, Hirokazu; Hoshino, Yu.

Coupling and Decoupling of Diverse Molecular Units in Glycosciences. Springer International Publishing, 2017. p. 213-224.

研究成果: 著書/レポートタイプへの貢献

Miura, Y, Fukuda, T, Seto, H & Hoshino, Y 2017, Syntheses and functions of Glycosaminoglycan mimicking polymers. : Coupling and Decoupling of Diverse Molecular Units in Glycosciences. Springer International Publishing, pp. 213-224. https://doi.org/10.1007/978-3-319-65587-1_10
Miura Y, Fukuda T, Seto H, Hoshino Y. Syntheses and functions of Glycosaminoglycan mimicking polymers. : Coupling and Decoupling of Diverse Molecular Units in Glycosciences. Springer International Publishing. 2017. p. 213-224 https://doi.org/10.1007/978-3-319-65587-1_10
Miura, Yoshiko ; Fukuda, Tomohiro ; Seto, Hirokazu ; Hoshino, Yu. / Syntheses and functions of Glycosaminoglycan mimicking polymers. Coupling and Decoupling of Diverse Molecular Units in Glycosciences. Springer International Publishing, 2017. pp. 213-224
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