Syntheses and functions of Glycosaminoglycan mimicking polymers

Yoshiko Miura, Tomohiro Fukuda, Hirokazu Seto, Yu Hoshino

研究成果: Chapter in Book/Report/Conference proceedingChapter

抄録

Glycosaminoglycans (GAGs) are important polysaccharides in the living system. Though total syntheses of GAGs oligosaccharides have been reported, it is still difficult to obtain GAGs. In this investigation, GAGs mimetics were prepared by polymerization of vinyl sugars instead of total synthesis. Glycopolymers are polymers with pendant saccharides, and exhibit a strong molecular recognition due to the multivalency. GAGs mimicking glycopolymers were prepared by polymerizing acrylamide derivatives carrying sulfated N-acetyl glucosamine (GlcNAc). The polymer interactions with proteins were investigated. The glycopolymer libraries were prepared with varying molecular weight, sugar structure, and sugar ratios. The GAG glycopolymers with biodegradable backbone, dendrimer, and arrays were also prepared. The inhibitory activity of Alzheimer amyloid beta peptides by the glycopolymers was investigated in detail. The glycopolymer with sulfated GlcNAc inhibited the aggregation of amyloid beta (Aβ) and the multivalency of sulfated GlcNAc was the key of the interaction. The activity depends on the chemical structure of glycopolymers. Also, the sulfated saccharide function was correlated to the functions of native GAGs.

本文言語英語
ホスト出版物のタイトルCoupling and Decoupling of Diverse Molecular Units in Glycosciences
出版社Springer International Publishing
ページ213-224
ページ数12
ISBN(電子版)9783319655871
ISBN(印刷版)9783319655864
DOI
出版ステータス出版済み - 11 20 2017

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Engineering(all)
  • Materials Science(all)

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