It has become possible to synthesize all possible calixarene derivatives with MeO-and ROCOCH2O- substituents from corresponding O-methylated calixarenes(2-7). The yields of these reactions were relatively high and the products could be easily purified because of the absence of other regioisomers. They are one mono-, three di-, three tri-, three tetra-, one penta-, and one hexa-EtOCOCH2O-substituted products. It was proved that O-methylation products act as useful basic skeletons to design functionalized calixarenes with the desired number of ROCOCH2O substituents and the regioselectively-positioned ROCOCH2O groups.
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