Syntheses of large-membered macrocycles having multiple hydrogen bonding moieties

Hisashi Shimakoshi, Takayuki Kai, Isao Aritome, Yoshio Hisaeda

    研究成果: Contribution to journalArticle査読

    24 被引用数 (Scopus)

    抄録

    New macrocyclic compounds have been synthesized by Schiff-base condensation reaction with methylenebis(4,4′-methyl-6,6′-salicylaldehyde) and 1,2-bis(2-aminoethoxy)ethane based on a high dilution method. [2+2], [3+3], and [4+4]-Cyclocondenced products were effectively isolated and characterized by 1H NMR and HR mass (FAB) spectroscopies as well as X-ray analyses. Reduction of the macrocycles with NaBH4 afforded the corresponding multi-amino, multi-phenolic macrocyclic compounds. The reduced molecules have low energy barriers for conformation change, which are estimated by variable-temperature (VT) 1H NMR study.

    本文言語英語
    ページ(範囲)8261-8264
    ページ数4
    ジャーナルTetrahedron Letters
    43
    46
    DOI
    出版ステータス出版済み - 11 11 2002

    All Science Journal Classification (ASJC) codes

    • 生化学
    • 創薬
    • 有機化学

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