Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

Hisashi Shimakoshi, Takeshi Kaieda, Takashi Matsuo, Hideaki Sato, Yoshio Hisaeda

    研究成果: Contribution to journalArticle査読

    30 被引用数 (Scopus)

    抄録

    One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

    本文言語英語
    ページ(範囲)5197-5199
    ページ数3
    ジャーナルTetrahedron Letters
    44
    28
    DOI
    出版ステータス出版済み - 7 7 2003

    All Science Journal Classification (ASJC) codes

    • 生化学
    • 創薬
    • 有機化学

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