Synthesis and antiproliferative activity of ammonium and imidazolium ionic liquids against T98G brain cancer cells

Nagendra Kumar Kaushik, Pankaj Attri, Neha Kaushik, Eun Ha Choi

研究成果: Contribution to journalArticle査読

34 被引用数 (Scopus)

抄録

Four ammonium and imidazolium ionic liquids (ILs) have been synthesized and screened against the T98G cell line (brain cancer) and HEK normal cells. Treatment induced metabolic cell death (MTT), growth inhibition, clonogenic inhibition were studied as cellular response parameters. Treatment with ILs enhanced growth inhibition and cell death in a concentration dependent manner in both the T98G and HEK cell lines. At higher concentrations (>0.09 mg/mL) the cytotoxic effects of the ILs were highly significant. An inhibitory effect on clonogenic capacity was also observed after cell treatment. Amongst all ILs IL 4 (BMIMCl) exhibited potent activity against T98G brain cancer cells. Despite potent in-vitro activity, all ILs exhibited less cytotoxicity against the normal human HEK cells at all effective concentrations.

本文言語英語
ページ(範囲)13727-13739
ページ数13
ジャーナルMolecules
17
12
DOI
出版ステータス出版済み - 12 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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