抄録
We have already reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core for targeting liver cell. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-Dglucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α- D-galactopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.
本文言語 | 英語 |
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ページ数 | 1 |
出版ステータス | 出版済み - 12月 1 2005 |
イベント | 54th SPSJ Symposium on Macromolecules - Yamagata, 日本 継続期間: 9月 20 2005 → 9月 22 2005 |
その他
その他 | 54th SPSJ Symposium on Macromolecules |
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国/地域 | 日本 |
City | Yamagata |
Period | 9/20/05 → 9/22/05 |
!!!All Science Journal Classification (ASJC) codes
- 工学(全般)