抄録
We have already reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core for targeting liver cell. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-Dglucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α- D-galactopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.
| 元の言語 | 英語 |
|---|---|
| ページ数 | 1 |
| 出版物ステータス | 出版済み - 12 1 2005 |
| イベント | 54th SPSJ Symposium on Macromolecules - Yamagata, 日本 継続期間: 9 20 2005 → 9 22 2005 |
その他
| その他 | 54th SPSJ Symposium on Macromolecules |
|---|---|
| 国 | 日本 |
| 市 | Yamagata |
| 期間 | 9/20/05 → 9/22/05 |
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All Science Journal Classification (ASJC) codes
- Engineering(all)
これを引用
Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core. / Fukui, Takaaki; Otsuka, Yoshiharu; Aoi, Keigo; Tanaka, Keiji; Nagamura, Toshihiko.
2005. 論文発表場所 54th SPSJ Symposium on Macromolecules, Yamagata, 日本.研究成果: 会議への寄与タイプ › 論文
}
TY - CONF
T1 - Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core
AU - Fukui, Takaaki
AU - Otsuka, Yoshiharu
AU - Aoi, Keigo
AU - Tanaka, Keiji
AU - Nagamura, Toshihiko
PY - 2005/12/1
Y1 - 2005/12/1
N2 - We have already reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core for targeting liver cell. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-Dglucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α- D-galactopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.
AB - We have already reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core for targeting liver cell. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-Dglucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α- D-galactopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.
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M3 - Paper
AN - SCOPUS:33645647467
ER -