TY - JOUR
T1 - Synthesis and Binding Properties of Monomeric and Dimeric Guanine and Cytosine Amine Derivatives
AU - Sessler, Jonathan L.
AU - Magda, Darren
AU - Furuta, Hiroyuki
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The syntheses of the N-protected forms of the cytosine homodimer 1, the guanine cytosine heterodimer 2, and the guanine homodimer 3 are described. Derivatization of these dimers, as well as the protected monomers corresponding to 4 and 5, with ω-methoxypoly(ethylene glycol)-α-carboxylic acid 26 and subsequent deprotection formed the amides 29, 31, 33, 35, and 37. The binding properties of these solubilized compounds in DMSO-d6 were examined using 1H NMR.
AB - The syntheses of the N-protected forms of the cytosine homodimer 1, the guanine cytosine heterodimer 2, and the guanine homodimer 3 are described. Derivatization of these dimers, as well as the protected monomers corresponding to 4 and 5, with ω-methoxypoly(ethylene glycol)-α-carboxylic acid 26 and subsequent deprotection formed the amides 29, 31, 33, 35, and 37. The binding properties of these solubilized compounds in DMSO-d6 were examined using 1H NMR.
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U2 - 10.1021/jo00029a008
DO - 10.1021/jo00029a008
M3 - Article
AN - SCOPUS:0026551398
SN - 0022-3263
VL - 57
SP - 818
EP - 826
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 3
ER -