Two phencyclidine (PCP) analogs, 3 and 4, and one thienylcyclohexylpiperidine (TCP) analog, (±)6, were labeled with positron emitter carbon-11. These compounds displayed higher in vitro binding affinities than PCP itself for the PCP-binding site located inside the ion channel on the N-methyl-D-aspartate (NMDA) receptors. Brain distribution studies in mice showed different uptake characteristics between the PCP and TCP analogs, indicating their different in vivo interactions with the brain components including the PCP-binding site probably due to the different physicochemical properties of the molecules.
|ジャーナル||Journal of Labelled Compounds and Radiopharmaceuticals|
|出版ステータス||出版済み - 9 1 1998|
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