Synthesis and brain distribution of carbon-11 labeled analogs of antagonists for the NMDA receptor coupled PCP-binding site

Terushi Haradahira, Sigeki Sasaki, Minoru Maeda, Kaoru Kobayashi, Osamu Inoue, Urara Tomita, Toru Nishikawa, Kazutoshi Suzuki

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

Two phencyclidine (PCP) analogs, 3 and 4, and one thienylcyclohexylpiperidine (TCP) analog, (±)6, were labeled with positron emitter carbon-11. These compounds displayed higher in vitro binding affinities than PCP itself for the PCP-binding site located inside the ion channel on the N-methyl-D-aspartate (NMDA) receptors. Brain distribution studies in mice showed different uptake characteristics between the PCP and TCP analogs, indicating their different in vivo interactions with the brain components including the PCP-binding site probably due to the different physicochemical properties of the molecules.

本文言語英語
ページ(範囲)843-858
ページ数16
ジャーナルJournal of Labelled Compounds and Radiopharmaceuticals
41
9
DOI
出版ステータス出版済み - 9 1 1998

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 放射線学、核医学およびイメージング
  • 創薬
  • 分光学
  • 有機化学

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