Synthesis and metal-binding properties of oligo-calixarenes. an approach towards the calix[4]arene-based dendrimers

Pavel Lhotak, Seiji Shinkai

研究成果: Contribution to journalArticle査読

46 被引用数 (Scopus)

抄録

A series of bis-calix[4]arene derivatives 4a-h (cone conformation) linked through the phenolic oxygens with the help of a single aliphatic chain (lower rim-lower rim connection) was obtained in high yields (50-80%) by alkylation of 25, 26, 27-tripropoxy-28-hydroxycalix[4]arenes 2a, 2b with 0.5 equiv. of Br-(CH2)n-Br in the presence of NaH. The same reaction with excess dibromides yielded corresponding bromoalkyl derivatives 3a-c which were used for construction of oligo-calix[4]arenes (bis, tris, pentakis) - a new family of calix[4]arene derivatives representing the first step on the way towards the calixarene-based dendrimers. The metal complexation behavior of newly prepared compounds was investigated with the help of 1H NMR spectroscopy.

本文言語英語
ページ(範囲)7681-7696
ページ数16
ジャーナルTetrahedron
51
28
DOI
出版ステータス出版済み - 7 10 1995

All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

フィンガープリント

「Synthesis and metal-binding properties of oligo-calixarenes. an approach towards the calix[4]arene-based dendrimers」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル