Synthesis and properties of a new class of nucleosides with spin source.

Mariko Aso, T. Ikeno, T. Kaneko, N. Koga, H. Suemune

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Novel spin-labeled ribonucleosides 1-5 were synthesized to investigate stability and behavior of N-tert-butyl aminoxyl radical on nucleobase. Site selective lithiation of tri-O-protected ribonucleosides followed by the reaction with 2-methyl-2-nitrosopropane (MNP) resulted in introduction of N-tert-butylhydroxylamino group into various positions of purine or pyrimidine nucleus. Oxidation of the obtained hydroxylamines with Ag2O led to formation of 1-5. EPR study showed that the unpaired electron of the aminoxyl radical was delocalized into the nucleobase and hyperfine structures were dependent on the position of the radical.

元の言語英語
ページ(範囲)115-116
ページ数2
ジャーナルNucleic acids research. Supplement (2001)
発行部数1
出版物ステータス出版済み - 1 1 2001

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Ribonucleosides
Nucleosides
Hydroxylamines
Electrons
tert-nitrosobutane
pyrimidine
purine

これを引用

Synthesis and properties of a new class of nucleosides with spin source. / Aso, Mariko; Ikeno, T.; Kaneko, T.; Koga, N.; Suemune, H.

:: Nucleic acids research. Supplement (2001), 番号 1, 01.01.2001, p. 115-116.

研究成果: ジャーナルへの寄稿記事

Aso, Mariko ; Ikeno, T. ; Kaneko, T. ; Koga, N. ; Suemune, H. / Synthesis and properties of a new class of nucleosides with spin source. :: Nucleic acids research. Supplement (2001). 2001 ; 番号 1. pp. 115-116.
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