Synthesis of 12- O-Mono- and Diglycosyl-oxystearates, a New Class of Agonists for the C-type Lectin Receptor Mincle

Le Van Huy, Chiaki Tanaka, Takashi Imai, Sho Yamasaki, Tomofumi Miyamoto

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Fifteen glycosyl-oxystearates were synthesized by Crich's 4,6-benzylidene and Köening-Knorr strategies. Assessment of structure-activity relationships using macrophage-inducible C-type lectin (Mincle) receptor cells expressing nuclear factor of activated T cells (NFAT)-green fluorescent protein (GFP) revealed that four dimannopyranosyl-oxystearate analogues were Mincle agonists and that 12-O-(2-O-α-d-mannopyranosyl)-α-d-mannopyranosyl-oxystearate was as an activator of both mouse and human Mincle.

元の言語英語
ページ(範囲)44-49
ページ数6
ジャーナルACS Medicinal Chemistry Letters
10
発行部数1
DOI
出版物ステータス出版済み - 10 1 2019

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C-Type Lectins
Macrophages
NFATC Transcription Factors
Structure-Activity Relationship
Green Fluorescent Proteins
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

これを引用

Synthesis of 12- O-Mono- and Diglycosyl-oxystearates, a New Class of Agonists for the C-type Lectin Receptor Mincle. / Van Huy, Le; Tanaka, Chiaki; Imai, Takashi; Yamasaki, Sho; Miyamoto, Tomofumi.

:: ACS Medicinal Chemistry Letters, 巻 10, 番号 1, 01.10.2019, p. 44-49.

研究成果: ジャーナルへの寄稿記事

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abstract = "Fifteen glycosyl-oxystearates were synthesized by Crich's 4,6-benzylidene and K{\"o}ening-Knorr strategies. Assessment of structure-activity relationships using macrophage-inducible C-type lectin (Mincle) receptor cells expressing nuclear factor of activated T cells (NFAT)-green fluorescent protein (GFP) revealed that four dimannopyranosyl-oxystearate analogues were Mincle agonists and that 12-O-(2-O-α-d-mannopyranosyl)-α-d-mannopyranosyl-oxystearate was as an activator of both mouse and human Mincle.",
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AU - Miyamoto, Tomofumi

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