Synthesis of 25- 13c-amphotericin B methyl ester: A molecular probe for solid-state NMR measurements

Naohiro Matsushita, Yukiko Matsuo, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio Murata, Tohru Oishi

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

A 13C-labeled amphotericin B (AmB) derivative was synthesized based on a hybrid strategy combining chemical synthesis with degradation of a natural product through successive cross-coupling reactions and macrolactonization. The specimen regiospecifically 13C-labeled (99% enrichment) at C25 position corresponding to the polyene moiety would be a powerful tool for structural analysis of the molecular assembly formed by AmB based on solid-state NMR measurements.

元の言語英語
ページ(範囲)114-115
ページ数2
ジャーナルChemistry Letters
38
発行部数2
DOI
出版物ステータス出版済み - 7 20 2009
外部発表Yes

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Molecular Probes
Amphotericin B
Nuclear magnetic resonance
Polyenes
Biological Products
Structural analysis
Derivatives
Degradation
methylamphotericin B

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

これを引用

Synthesis of 25- 13c-amphotericin B methyl ester : A molecular probe for solid-state NMR measurements. / Matsushita, Naohiro; Matsuo, Yukiko; Tsuchikawa, Hiroshi; Matsumori, Nobuaki; Murata, Michio; Oishi, Tohru.

:: Chemistry Letters, 巻 38, 番号 2, 20.07.2009, p. 114-115.

研究成果: ジャーナルへの寄稿記事

Matsushita, Naohiro ; Matsuo, Yukiko ; Tsuchikawa, Hiroshi ; Matsumori, Nobuaki ; Murata, Michio ; Oishi, Tohru. / Synthesis of 25- 13c-amphotericin B methyl ester : A molecular probe for solid-state NMR measurements. :: Chemistry Letters. 2009 ; 巻 38, 番号 2. pp. 114-115.
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