Synthesis of 28- 19 F-amphotericin B methyl ester

Hiroshi Tsuchikawa, Naohiro Matsushita, Nobuaki Matsumori, Michio Murata, Tohru Oishi

研究成果: Contribution to journalArticle

35 引用 (Scopus)

抜粋

A fluorinated amphotericin B (AmB) derivative, 28- 19 F-AmB methyl ester (3), labeled at the polyene moiety, was synthesized by combining chemical synthesis with degradation of a natural product via cross-coupling reactions and macrolactonization. The fluorinated derivative 3 showed antifungal activity similar to that of AmB, and is expected to be a powerful tool for NMR-based investigation of the mechanism of ion-channel formation.

元の言語英語
ページ(範囲)6187-6191
ページ数5
ジャーナルTetrahedron Letters
47
発行部数35
DOI
出版物ステータス出版済み - 8 28 2006
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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