Synthesis of a bio-inspired catechol/phosphorylcholine surface modifier and characterization of its surface properties

Yucheng Zhang, Tomoyasu Hirai, Wei Ma, Yuji Higaki, Ken Kojio, Atsushi Takahara

研究成果: ジャーナルへの寄稿記事

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Biocompatible and blood-compatible surface modification is urgently needed for stainless steel (SUS)-based human implant devices to avoid inflammation and biofouling. To this end, the use of polymeric surface modifiers, whose surface properties are specifically tailored, is a promising approach since this approach minimizes the impact on device's mechanical properties. However, adhesion between the device and surface modifier is relatively weak, since van der Waals forces are employed, leading to low device durability. To address this issue, this work functionalized poly(ɛ-caprolactone)-b-[poly(α-chloride-ɛ-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine)]2 (PCL-b-(PCL-Cl-b-PMPC)2) with catechol groups via a nucleophilic substitution, whereby the catechol functionalization was optimized. The resultant surface modifier showed strong adhesion toward SUS surfaces, forming a smooth and uniform hydrophilic polymeric film that reduced SUS fouling (i.e., protein). Notably, no significant changes of adhesion between the SUS and thin films (thin film) were observed after immersion for 45 days in a pH 7.4 phosphate buffer solution.

元の言語英語
ページ(範囲)38-49
ページ数12
ジャーナルJournal of Polymer Science, Part A: Polymer Chemistry
56
発行部数1
DOI
出版物ステータス出版済み - 1 1 2018

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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