Synthesis of a new class of spin-labeled purine ribonucleosides and development of a novel nucleophilic reaction to form 2,6,8-trifunctionalized purine derivatives

Mariko Aso, Kouji Norihisa, Masakazu Tanaka, Noboru Koga, Hiroshi Suemune

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Novel purine ribonucleosides with a tert-butylhydroxy-amino function at the C8-position of the purine nucleus were synthesized, and were oxidized to aminoxyl radicals by treatment with Ag2O; after O-acylation of the tert-butylhydroxyamino group, nucleophilic substitution at the C2-position of the purine nucleus easily proceeded with elimination of the N-acyloxy group to provide a novel method for preparing C2-functionalized purine ribonucleosides.

本文言語英語
ページ(範囲)1637-1638
ページ数2
ジャーナルJournal of the Chemical Society. Perkin Transactions 2
8
DOI
出版ステータス出版済み - 8 2000

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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