Novel purine ribonucleosides with a tert-butylhydroxy-amino function at the C8-position of the purine nucleus were synthesized, and were oxidized to aminoxyl radicals by treatment with Ag2O; after O-acylation of the tert-butylhydroxyamino group, nucleophilic substitution at the C2-position of the purine nucleus easily proceeded with elimination of the N-acyloxy group to provide a novel method for preparing C2-functionalized purine ribonucleosides.
|ジャーナル||Journal of the Chemical Society. Perkin Transactions 2|
|出版物ステータス||出版済み - 8 2000|
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