Synthesis of a truncated analog of amphidinol 3 corresponding to the C21C39/C52C67 section

Makoto Ebine, Yuri Takada, Naoto Yanai, Tohru Oishi

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

As a part of structureactivity relationship studies to elucidate structure requirements for eliciting antifungal activity, an artificial analog of amphidinol 3 (AM3) was designed. A truncated analog corresponding to the C21C39/C52C67 section was synthesized by using SuzukiMiyaura coupling and JuliaKocienski olefination as key steps. An expeditious and versatile method to construct the C53C67 polyene section was also developed based on a linchpin strategy via successive cross-coupling reactions. The analog elicited no antifungal activity, suggesting that the two tetrahydropyran rings of AM3 are necessary to elicit antifungal activity.

元の言語英語
ページ(範囲)662-664
ページ数3
ジャーナルChemistry Letters
46
発行部数5
DOI
出版物ステータス出版済み - 1 1 2017

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Polyenes
amphidinol 3

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

これを引用

Synthesis of a truncated analog of amphidinol 3 corresponding to the C21C39/C52C67 section. / Ebine, Makoto; Takada, Yuri; Yanai, Naoto; Oishi, Tohru.

:: Chemistry Letters, 巻 46, 番号 5, 01.01.2017, p. 662-664.

研究成果: ジャーナルへの寄稿記事

Ebine, Makoto ; Takada, Yuri ; Yanai, Naoto ; Oishi, Tohru. / Synthesis of a truncated analog of amphidinol 3 corresponding to the C21C39/C52C67 section. :: Chemistry Letters. 2017 ; 巻 46, 番号 5. pp. 662-664.
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