Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists

Yu Mikame, Kazuko Yoshida, Daisuke Hashizume, Go Hirai, Kazuo Nagasawa, Hiroyuki Osada, Mikiko Sodeoka

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

The PYR/PYL/RCAR protein families have recently emerged as receptors of the phytohormone abscisic acid (ABA, 1), which regulates plant responses to environmental stress. These families have multiple members with different physiological actions, and so selective agonists or antagonists are needed both as tools to elucidate functional differences and as lead compounds for agrochemicals. We previously identified RK460 (rac-3 a) as a PYR1-selective antagonist, and showed that it possesses five stereocenters on a 6,5-cis-bicyclo skeleton. Here, we synthesized all the stereoisomers of RK460 and evaluated their activity towards a panel of receptors. Relative stereochemistry as well as absolute stereochemistry was important for selective action.

元の言語英語
ページ(範囲)3496-3500
ページ数5
ジャーナルChemistry - A European Journal
25
発行部数14
DOI
出版物ステータス出版済み - 3 7 2019

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Abscisic Acid
Stereochemistry
Stereoisomerism
Agrochemicals
Lead compounds
Plant Growth Regulators
Acids
Proteins

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

これを引用

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists. / Mikame, Yu; Yoshida, Kazuko; Hashizume, Daisuke; Hirai, Go; Nagasawa, Kazuo; Osada, Hiroyuki; Sodeoka, Mikiko.

:: Chemistry - A European Journal, 巻 25, 番号 14, 07.03.2019, p. 3496-3500.

研究成果: ジャーナルへの寄稿記事

Mikame, Yu ; Yoshida, Kazuko ; Hashizume, Daisuke ; Hirai, Go ; Nagasawa, Kazuo ; Osada, Hiroyuki ; Sodeoka, Mikiko. / Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists. :: Chemistry - A European Journal. 2019 ; 巻 25, 番号 14. pp. 3496-3500.
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