Previously, we reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-acetyl-β-D- galactopyranosyl)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl trichloroacetimidate followed by deacetylation. Chemical structures of the dendrimers were determined by1H-NMR, 1H-1H COSY and MALDI-TOF MS analyses.
|出版ステータス||出版済み - 12 1 2005|
|イベント||54th SPSJ Annual Meeting 2005 - Yokohama, 日本|
継続期間: 5 25 2005 → 5 27 2005
|その他||54th SPSJ Annual Meeting 2005|
|Period||5/25/05 → 5/27/05|
All Science Journal Classification (ASJC) codes