Synthesis of amphiphilic lactose-substituted polyether dendrimers

Keigo Aoi, Takaaki Fukui, Yoshiharu Otsuka, Tadao Kondo, Keiji Tanaka, Toshihiko Nagamura

    研究成果: Contribution to conferencePaper査読

    抄録

    Previously, we reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-acetyl-β-D- galactopyranosyl)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl trichloroacetimidate followed by deacetylation. Chemical structures of the dendrimers were determined by1H-NMR, 1H-1H COSY and MALDI-TOF MS analyses.

    本文言語英語
    ページ数1
    出版ステータス出版済み - 12 1 2005
    イベント54th SPSJ Annual Meeting 2005 - Yokohama, 日本
    継続期間: 5 25 20055 27 2005

    その他

    その他54th SPSJ Annual Meeting 2005
    国/地域日本
    CityYokohama
    Period5/25/055/27/05

    All Science Journal Classification (ASJC) codes

    • 工学(全般)

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