Our purpose is to create new biomedical materials with controlled sugar array having intervals on a nanoscale by organization. The plane arrangement of the dendrimers was shown to be able to control the intersugar distance at nano-level. We have already reported synthesis of amphiphilic aliphatic polyether dendrimers having a sugar residue at the core. In this report, we synthesized amphiphilic adamantyl-ended polyether dendrimers having a lactose or galactose residue at the core. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxyl-type adamantyl-terminal aliphatic polyether dendrimer and 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl trichloroacetimidate or 4-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-D-glucopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.
|出版物ステータス||出版済み - 10 18 2006|
|イベント||55th SPSJ Annual Meeting - Nagoya, 日本|
継続期間: 5 24 2006 → 5 26 2006
|その他||55th SPSJ Annual Meeting|
|期間||5/24/06 → 5/26/06|
All Science Journal Classification (ASJC) codes