Synthesis of an analog of amphidinol 3 corresponding to the c31-c67 section

Tomoyuki Koge, Yuma Wakamiya, Makoto Ebine, Tohru Oishi

研究成果: ジャーナルへの寄稿記事

抄録

An artificial analog corresponding to the C31-C67 section of amphidinol 3 (AM3) was designed as a part of the structure-activity relationship studies to elucidate structure requirements for eliciting antifungal activity. To reduce the number of synthetic steps, the 43-deoxy-51-epi derivative containing common tetrahydropyran ring system was designed and synthesized from a pivotal intermediate in 17 steps. The analog elicited no antifungal activity, suggesting that not only the two tetrahydropyran rings, but also polyol section of AM3 are necessary to elicit antifungal activity.

元の言語英語
ページ(範囲)1197-1202
ページ数6
ジャーナルHeterocycles
96
発行部数7
DOI
出版物ステータス出版済み - 1 1 2018

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Structure-Activity Relationship
Derivatives
amphidinol 3
polyol

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

これを引用

Synthesis of an analog of amphidinol 3 corresponding to the c31-c67 section. / Koge, Tomoyuki; Wakamiya, Yuma; Ebine, Makoto; Oishi, Tohru.

:: Heterocycles, 巻 96, 番号 7, 01.01.2018, p. 1197-1202.

研究成果: ジャーナルへの寄稿記事

Koge, Tomoyuki ; Wakamiya, Yuma ; Ebine, Makoto ; Oishi, Tohru. / Synthesis of an analog of amphidinol 3 corresponding to the c31-c67 section. :: Heterocycles. 2018 ; 巻 96, 番号 7. pp. 1197-1202.
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