Synthesis of calcium phosphate-binding liposome for drug delivery

Takahisa Anada, Yoichi Takeda, Yoshitomo Honda, Kazuo Sakurai, Osamu Suzuki

研究成果: Contribution to journalArticle査読

49 被引用数 (Scopus)

抄録

Metastatic bone disease is often associated with bone pain, pathologic fractures, and nerve compression syndromes. Effective therapies to inhibit the progression of bone metastases would have important clinical benefits. Therefore, we developed a novel calcium phosphate-binding liposome for a bone-targeting drug delivery system. We synthesized a novel amphipathic molecule bearing a bisphosphonate (BP) head group to recognize and bind to hydroxyapatite (HA). We demonstrated that the liposomes having BP moieties show high affinity for HA. Doxorubicin-loaded liposomes adsorbed on the surface of HA significantly reduce the number of viable human osteosarcoma MG63 cells. This shows that the liposomes can be excellent carriers for anticancer drugs because they specifically target bone tissue. This calcium phosphate-binding liposome system could be used with many drugs for bone-related diseases such as osteoporosis, rheumatoid arthritis, and multiple myeloma.

本文言語英語
ページ(範囲)4148-4150
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
19
15
DOI
出版ステータス出版済み - 8 1 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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