Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N2 containing 0%, 5%, or 15% CO2 by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO43- and OH- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β2-microgloburin (β2-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β2-MG (47%). It was concluded that the selective adsorption activity against β2-MG was related to the carbonate ions incorporated in hydroxyapatite.
|ジャーナル||Key Engineering Materials|
|出版ステータス||出版済み - 1月 1 2002|
|イベント||14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM) - Palm Springs, CA, 米国|
継続期間: 11月 14 2001 → 11月 17 2001
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