Synthesis of DNA-peptide conjugates by solid-phase fragment condensation

Takanori Kubo, Masaaki Morikawa, Hideki Ohba, Masayuki Fujii

研究成果: Contribution to journalArticle査読

23 被引用数 (Scopus)

抄録

(Matrix presented) DNA-peptide conjugates were synthesized by condensing partially protected peptide fragments and oligonucleotides on a CPG support using diisocyanatoalkane as a linker. After cleavage and deprotection with aqueous ammonia, pure products were obtained by single RPHPLC purification in satisfactory yields and identified by a MALDI-TOF MS spectrometer. This method allows one to prepare DNA-peptide conjugates with any components and sequences of DNA and peptides.

本文言語英語
ページ(範囲)2623-2626
ページ数4
ジャーナルOrganic Letters
5
15
DOI
出版ステータス出版済み - 7 24 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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