Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control

Keiko Terada, Yuko Sato, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

    研究成果: Contribution to conferencePaper査読

    抄録

    We designed gene carriers that can activate the delivered gene in response to the intercellular kinase signal. 'c-Src', which is a non-receptor tyrosine kinase, is specifically activated within a cancer cell. Our goal is to create various gene carriers to express a therapeutic gene in response to 'c-Src' activity. First, we synthesized some polymers that are grafted with c-Src substrate peptides as an intercellular signal-response gene carrier. Then, we evaluated whether those carriers can regulate gene expression in cell free system. We will discuss the relation between the carrier design and their abilities for signal specific gene regulation.

    本文言語英語
    ページ数1
    出版ステータス出版済み - 12 1 2006
    イベント55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本
    継続期間: 9 20 20069 22 2006

    その他

    その他55th Society of Polymer Science Japan Symposium on Macromolecules
    国/地域日本
    CityToyama
    Period9/20/069/22/06

    All Science Journal Classification (ASJC) codes

    • 工学(全般)

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