Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.

Mariko Aso, Mitsuhiro Fukuda, Kazuteru Usui, Hiroshi Suemune

研究成果: ジャーナルへの寄稿会談の抜粋

抄録

We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

元の言語英語
ページ(範囲)59-60
ページ数2
ジャーナルNucleic acids symposium series (2004)
発行部数48
出版物ステータス出版済み - 1 1 2004

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Oligonucleotides
Lewis Acids
Thymidine
4'-o-nitrobenzyloxythymidine
3-chloroperbenzoic acid

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity. / Aso, Mariko; Fukuda, Mitsuhiro; Usui, Kazuteru; Suemune, Hiroshi.

:: Nucleic acids symposium series (2004), 番号 48, 01.01.2004, p. 59-60.

研究成果: ジャーナルへの寄稿会談の抜粋

Aso, Mariko ; Fukuda, Mitsuhiro ; Usui, Kazuteru ; Suemune, Hiroshi. / Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity. :: Nucleic acids symposium series (2004). 2004 ; 番号 48. pp. 59-60.
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abstract = "We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.",
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