Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.

Mariko Aso; Mitsuhiro Fukuda; Kazuteru Usui; Hiroshi Suemune

Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.

Mariko Aso, Mitsuhiro Fukuda, Kazuteru Usui, Hiroshi Suemune

医薬化学

研究成果: Contribution to journal › Meeting Abstract

抄録

We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

本文言語	英語
ページ（範囲）	59-60
ページ数	2
ジャーナル	Nucleic acids symposium series (2004)
号	48
出版ステータス	出版済み - 2004

All Science Journal Classification (ASJC) codes

Medicine(all)

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引用スタイル

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title = "Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.",

abstract = "We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.",

author = "Mariko Aso and Mitsuhiro Fukuda and Kazuteru Usui and Hiroshi Suemune",

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AU - Aso, Mariko

AU - Fukuda, Mitsuhiro

AU - Usui, Kazuteru

AU - Suemune, Hiroshi

PY - 2004

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N2 - We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

AB - We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

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M3 - Meeting Abstract

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EP - 60

JO - Nucleic acids symposium series (2004)

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