Synthesis of optically active (R)- And (S)-β-arginine from pyroglutamic acid

Yoko Yasuno, Akira Sawai, Ai Sekihara, Tetsuro Shinada

研究成果: Contribution to journalArticle

1 被引用数 (Scopus)

抄録

– The first synthesis of optically active β-arginine was achieved starting from commercially available pyroglutamic acid. The new synthetic protocol is characterized by the use of nitrile as a carboxylic acid surrogate which could be transformed to the corresponding 2-acyl-1,3-bis(1,1-dimethylethyl)imidodi-carbonic acid ester (active amide) via Pt-catalyzed hydration under the mild conditions. The active amide was converted to β-arginine and Boc-β-Arg-Val-OMe in good yield.

本文言語英語
ページ(範囲)165-176
ページ数12
ジャーナルHeterocycles
101
1
DOI
出版ステータス出版済み - 1 1 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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