Synthesis of pectin-N, N-dimethyl acrylamide hydrogel by gamma radiation and application in drug delivery (in vitro)

Md Murshed Bhuyan, Hirotaka Okabe, Yoshiki Hidaka, Nirmal Chandra Dafader, Nazia Rahman, Kazuhiro Hara

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The objective of the work is to synthesize pectin-N, N-Dimethylacrylamide (DMAA) hydrogel by gamma radiation without using any initiators and cross-linking agents. Effect of radiation doses on gel fraction and equilibrium swelling as a function of pH were studied, and 5 kGy radiation dose was found to be the optimum dose for hydrogel synthesis. The grafting /crosslinking was investigated by Fourier transform infrared spectroscopy. Thermal properties and surface morphology were studied by differential scanning calorimetry and scanning electron microscopy. To study the drug release kinetics, 5-fluorouracil was loaded into the hydrogel and in vitro release was carried out in simulated gastric and intestinal fluid. The release profile of drug showed that more than 90% of the loaded drugs were released after 4 hours at both gastric fluid and intestinal fluid pH. Drug release data was fitted into zero order, Higuchi and Korsmeyer-Peppas kinetic models. Higuchi model was found to be the best fitted and release exponent ‘n’ value of Korsmeyer-Peppas model indicated the non-Fickian transport.

元の言語英語
ページ(範囲)369-376
ページ数8
ジャーナルJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
55
発行部数4
DOI
出版物ステータス出版済み - 4 3 2018

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

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