Synthesis of sialyl Lewis X pentasaccharide analogue for high-throughput screening of selectin blockers

Takao Kiyoi, Yoshimasa Inoue, Hiroshi Ohmoto, Masahiro Yoshida, Makoto Kiso, Hirosato Kondo

研究成果: ジャーナルへの寄稿記事

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We have developed an effective synthesis of sLe(x) pentasaccharide glycolipid analogue 2. As a part of application of sLe(x) pentasaccharide glycolipid 2 synthesized here, we have investigated the construction of a high-throughput screening system for discovery of selectin blockers. As a result, it was found that compound 2 was a useful ligand for in vitro ELISA assay and could be an important material for high-throughput screening of selectin blockers. Copyright (C) 1998 Elsevier Science Ltd.

元の言語英語
ページ(範囲)587-593
ページ数7
ジャーナルBioorganic and Medicinal Chemistry
6
発行部数5
DOI
出版物ステータス出版済み - 5 1 1998
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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