Synthesis of sialyl Lewis X pentasaccharide analogue for high-throughput screening of selectin blockers

Takao Kiyoi; Yoshimasa Inoue; Hiroshi Ohmoto; Masahiro Yoshida; Makoto Kiso; Hirosato Kondo

doi:10.1016/S0968-0896(98)00003-0

Synthesis of sialyl Lewis X pentasaccharide analogue for high-throughput screening of selectin blockers

Takao Kiyoi, Yoshimasa Inoue, Hiroshi Ohmoto, Masahiro Yoshida, Makoto Kiso, Hirosato Kondo

研究成果: ジャーナルへの寄稿 › 記事

6 引用（Scopus）

抜粋

We have developed an effective synthesis of sLe(x) pentasaccharide glycolipid analogue 2. As a part of application of sLe(x) pentasaccharide glycolipid 2 synthesized here, we have investigated the construction of a high-throughput screening system for discovery of selectin blockers. As a result, it was found that compound 2 was a useful ligand for in vitro ELISA assay and could be an important material for high-throughput screening of selectin blockers. Copyright (C) 1998 Elsevier Science Ltd.

元の言語	英語
ページ（範囲）	587-593
ページ数	7
ジャーナル	Bioorganic and Medicinal Chemistry
巻	6
発行部数	5
DOI	https://doi.org/10.1016/S0968-0896(98)00003-0
出版物ステータス	出版済み - 5 1 1998
外部発表	Yes

フィンガープリント

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

これを引用

Kiyoi, T., Inoue, Y., Ohmoto, H., Yoshida, M., Kiso, M., & Kondo, H. (1998). Synthesis of sialyl Lewis X pentasaccharide analogue for high-throughput screening of selectin blockers. Bioorganic and Medicinal Chemistry, 6(5), 587-593. https://doi.org/10.1016/S0968-0896(98)00003-0

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AU - Kiso, Makoto

AU - Kondo, Hirosato

PY - 1998/5/1

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文献にアクセス

10.1016/S0968-0896(98)00003-0