TY - JOUR
T1 - Synthesis of sialyl Lewis X pentasaccharide analogue for high-throughput screening of selectin blockers
AU - Kiyoi, Takao
AU - Inoue, Yoshimasa
AU - Ohmoto, Hiroshi
AU - Yoshida, Masahiro
AU - Kiso, Makoto
AU - Kondo, Hirosato
PY - 1998/5/1
Y1 - 1998/5/1
N2 - We have developed an effective synthesis of sLe(x) pentasaccharide glycolipid analogue 2. As a part of application of sLe(x) pentasaccharide glycolipid 2 synthesized here, we have investigated the construction of a high-throughput screening system for discovery of selectin blockers. As a result, it was found that compound 2 was a useful ligand for in vitro ELISA assay and could be an important material for high-throughput screening of selectin blockers. Copyright (C) 1998 Elsevier Science Ltd.
AB - We have developed an effective synthesis of sLe(x) pentasaccharide glycolipid analogue 2. As a part of application of sLe(x) pentasaccharide glycolipid 2 synthesized here, we have investigated the construction of a high-throughput screening system for discovery of selectin blockers. As a result, it was found that compound 2 was a useful ligand for in vitro ELISA assay and could be an important material for high-throughput screening of selectin blockers. Copyright (C) 1998 Elsevier Science Ltd.
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U2 - 10.1016/S0968-0896(98)00003-0
DO - 10.1016/S0968-0896(98)00003-0
M3 - Article
C2 - 9629472
AN - SCOPUS:0031775823
VL - 6
SP - 587
EP - 593
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 5
ER -