Synthesis of simple sea cucumber ganglioside analogs

Ryuichi Higuchi, Takeshi Mori, Tetsuji Sugata, Koji Yamada, Tomofumi Miyamoto

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)

抄録

Two simple sea cucumber ganglioside analogs 8 (NeuAcα2→6 Glcβ 1→1 docosanol) and 9 (NeuAcβ2→6 Glcβ 1→1 docosanol), containing a long-chain alcohol as a mimic of ceramide, have been synthesized. Coupling of the methyl 2-thioglycoside derivative of N-acetylneuraminic acid S with docosyl glucoside derivative 3 afforded the protected ganglioside analogs 6 and 7, which were deprotected to give the corresponding ganglioside analogs 8 and 9, respectively. The 13C-NMR data obtained for these anomers 8 and 9 should prove useful for the determination of anomeric configurations of sialic acid residues in gangliosides.

本文言語英語
ページ(範囲)3175-3178
ページ数4
ジャーナルEuropean Journal of Organic Chemistry
11
DOI
出版ステータス出版済み - 11月 1999

!!!All Science Journal Classification (ASJC) codes

  • 物理化学および理論化学
  • 有機化学

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