Synthesis of the Right‐Side Structure of Type B Physalins

Masaki Morita, Shuntaro Kojima, Megumi Ohkubo, Hiroyuki Koshino, Daisuke Hashizume, Go Hirai, Keiji Maruoka, Mikiko Sodeoka

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

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We present a full account of our synthetic studies on the racemic DEFGH-ring moiety of physalins, featuring domino ring transformation of a tricyclic key intermediate. We also report the results of a detailed mechanistic examination of the domino ring transformation, as well as a reoptimization of the 2,3-Wittig rearrangement and methylation steps. Furthermore, we have newly established a method for the preparation of an optically active synthetic intermediate by enzymatic kinetic resolution. Our work provides access to both natural and nonnatural right-side physalin structures.
元の言語英語
ページ(範囲)309-318
ページ数10
ジャーナルIsrael Journal of Chemistry
57
発行部数3-4
DOI
出版物ステータス出版済み - 2017

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これを引用

Morita, M., Kojima, S., Ohkubo, M., Koshino, H., Hashizume, D., Hirai, G., ... Sodeoka, M. (2017). Synthesis of the Right‐Side Structure of Type B Physalins. Israel Journal of Chemistry, 57(3-4), 309-318. https://doi.org/10.1002/ijch.201600110