Synthesis of Xanthanolides including new acylations and their synthetic applications

Mitsuru Shindo, Kenji Matsumoto

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Xanthanolides were synthesized with intramolecular acylation of organolithium forming a sevenmembered carbocycle and one-pot acylation-Wittig lactonization as key steps. The Cu(II) complex efficiently catalyzed the acylation of thioester in Wittig lactonization under neutral conditions. Using the Cu(II) catalyst, symmetric dithiomalonates were converted into dissymmetric S,O-malonates via selective monoacylation. The key step in this reaction was the thermal formation of an acylketene, the stability of which would contribute to selectivity.

本文言語英語
ページ(範囲)1152-1162
ページ数11
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
71
11
DOI
出版ステータス出版済み - 2013

!!!All Science Journal Classification (ASJC) codes

  • 有機化学

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