Synthetic Method for 2′-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction

Hiroaki Sawamoto, Yuuki Arai, Shuhei Yamakoshi, Satoshi Obika, Eiji Kawanishi

研究成果: Contribution to journalArticle

2 引用 (Scopus)

抜粋

A transglycosylation reaction of 2′-amino-locked nucleic acid (LNA) from thymine (T) to other nucleobases adenine (A), guanine (G), and 5-methylcytosine (mC) has been developed. This reaction proceeds in high yield and with high β-selectivity. The mild reaction conditions enable the coexistence of acid-labile protecting groups, including a 4,4′-dimethoxytrytyl (DMTr) group. 2′-Amino-LNAs bearing any nucleobase can now be easily synthesized.

元の言語英語
ページ(範囲)1928-1931
ページ数4
ジャーナルOrganic Letters
20
発行部数7
DOI
出版物ステータス出版済み - 4 6 2018
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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