Synthetic receptor molecules for selective fluorescence detection of 8-oxo-dGTP in aqueous media

Yasufumi Fuchi, Takashi Fukuda, Shigeki Sasaki

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

A series of 9-hydroxy-1,3-diazaphenoxazine-2-one derivatives were synthesized as fluorescent receptor molecules for 8-oxo-dGTP, which attach the cyclen-zinc complex at the 3-N position as the binding site for the triphosphate and the (2-aryloxycarbonylamino)ethyl group at the 9-O position as the hydrogen bonding site for 8-oxoguanine. Among these molecules, the receptor molecule 5a-Zn constructed of the ethyl linker at 3-N and the (2-benzyloxycarbonyl amino)ethyl group at 9-O displayed the best recognition ability for 8-oxoguanosine triphosphate (8-oxo-dGTP) in aqueous media. The receptor 5a-Zn was also shown to selectively detect 8-oxo-dGTP in a cell lysate solution.

本文言語英語
ページ(範囲)7949-7955
ページ数7
ジャーナルOrganic and Biomolecular Chemistry
14
33
DOI
出版ステータス出版済み - 2016

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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