Synthetic studies on duocarmycin. 1. Total synthesis of dl-duocarmycin A and its 2-epimer

Yasumichi Fukuda, Yoshio Itoh, Kazuhiko Nakatani, Terashima Shiro

研究成果: Contribution to journalArticle査読

51 被引用数 (Scopus)

抄録

The title synthesis was first achieved by employing novel methoxycarbonylation of the C4-position of the 5-aminoindoline by way of the isatin and subsequent Dieckmann cyclization to the methyl 2-methylindoxyl-2-carboxylate as key steps. In vitro cytotoxicity assay against P388 murine leukemia obviously disclosed that cytotoxicities of the synthesized compounds are comparable and almost half of that of natural (+)-duocarmycin A.

本文言語英語
ページ(範囲)2793-2808
ページ数16
ジャーナルTetrahedron
50
9
DOI
出版ステータス出版済み - 2 28 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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