TY - CHAP
T1 - T cells in the brain inflammation
AU - Yoshimura, Akihiko
AU - Ohyagi, Masaki
AU - Ito, Minako
N1 - Funding Information:
This work was supported by JSPS KAKENHI 21H05044, 19H04817, 21K19382, 21H02719, 21H00432, 22K1944, 22B302, 20K22789, 21K15473, AMED-CREST 22gm1110009, MOON SHOT JP22zf0127003h, AMED-PRIME 22gm6210012, AMED- 22wm042501, the Yasuda Medical Foundation, Research grants from the Chemo-Sero-Therapeutic Research Institute, Yasuda Medical Prize, the Kishimoto Family Foundation, the Tomizawa Jun-ichi & Keiko Fund of Molecular Biology Society of Japan for Young Scientist, the Mitsubishi Foundation, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, the Takeda Science Foundation, the Uehara Memorial Foundation, the Naito Foundation, the Kanae Foundation, the SENSHIN Medical Research Foundation, the Astellas Foundation for Research on Metabolic Disorders, the Inoue Research Award for Young Scientists, a Life Science Research Award, and Keio Gijuku Academic Developmental Funds.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022
Y1 - 2022
N2 - The immune system is deeply involved in autoimmune diseases of the central nervous system (CNS), such as multiple sclerosis, N-methyl-D-aspartate (NMDA) receptor encephalitis, and narcolepsy. Additionally, the immune system is involved in various brain diseases including cerebral infarction and neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). In particular, reports related to T cells are increasing. T cells may also play important roles in brain deterioration and dementia that occur with aging. Our understanding of the role of immune cells in the context of the brain has been greatly improved by the use of acute ischemic brain injury models. Additionally, similar neural damage and repair events are shown to occur in more chronic brain neurodegenerative brain diseases. In this review, we focus on the role of T cells, including CD4+ T cells, CD8+ T cells and regulatory T cells (Tregs) in cerebral infarction and neurodegenerative diseases.
AB - The immune system is deeply involved in autoimmune diseases of the central nervous system (CNS), such as multiple sclerosis, N-methyl-D-aspartate (NMDA) receptor encephalitis, and narcolepsy. Additionally, the immune system is involved in various brain diseases including cerebral infarction and neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). In particular, reports related to T cells are increasing. T cells may also play important roles in brain deterioration and dementia that occur with aging. Our understanding of the role of immune cells in the context of the brain has been greatly improved by the use of acute ischemic brain injury models. Additionally, similar neural damage and repair events are shown to occur in more chronic brain neurodegenerative brain diseases. In this review, we focus on the role of T cells, including CD4+ T cells, CD8+ T cells and regulatory T cells (Tregs) in cerebral infarction and neurodegenerative diseases.
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U2 - 10.1016/bs.ai.2022.10.001
DO - 10.1016/bs.ai.2022.10.001
M3 - Chapter
AN - SCOPUS:85143545786
T3 - Advances in Immunology
BT - Advances in Immunology
PB - Academic Press Inc.
ER -