T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

Kuniomi Honda, Kazuhiko Nakamura, Noriaki Matsui, Makoto Takahashi, Yousuke Kitamura, Takahiro Mizutani, Naohiko Harada, Hajime Nawata, Shinjiro Hamano, Hiroki Yoshida

研究成果: ジャーナルへの寄稿記事

55 引用 (Scopus)

抄録

Background: WSX-1, a component of the interleukin (IL)-27 receptor, is a novel class I cytokine receptor with homology to the IL-12 receptor β2 chain. Initially, WSX-1 signaling was reported to play an important role in the promotion of T helper-1 responses, but recent reports have revealed an anti-inflammatory property in WSX-1 signaling. In the present study, we investigated the role of IL-27/WSX-1 signaling in a murine colitis model, dextran sulfate sodium (DSS) colitis, by using WSX-1 knockout (KO) mice. Methods: First, we observed whether WSX-1 KO mice developed colitis spontaneously. Second, we induced DSS colitis in WSX-1 KO and wild-type (WT) mice. Results: WSX-1 KO mice were observed not to develop colitis spontaneously. The severity of DSS colitis was decreased in WSX-1 KO mice in comparison with WT mice in association with a reduced production of interferon-γ, IL-6, and tumor necrosis factor-α by lamina propria mononuclear cells from WSX-1 KO mice and the absence of T-bet expression in the colon from WSX-1 KO mice. Conclusions: This study revealed the inflammatory property of IL-27/WSX-1 signaling in intestinal inflammation. As a result, IL-27/WSX-1 signal pathway may thus be a promising candidate for the therapeutic intervention of human inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.

元の言語英語
ページ(範囲)1044-1052
ページ数9
ジャーナルInflammatory Bowel Diseases
11
発行部数12
DOI
出版物ステータス出版済み - 12 1 2005

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Interleukin-27
Colitis
Knockout Mice
Dextran Sulfate
Interleukin-12 Receptors
Interleukin Receptors
Cytokine Receptors
Ulcerative Colitis
Inflammatory Bowel Diseases
Crohn Disease
Interferons
Interleukin-6
Signal Transduction
Colon
Mucous Membrane
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Inflammation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Gastroenterology

これを引用

Honda, K., Nakamura, K., Matsui, N., Takahashi, M., Kitamura, Y., Mizutani, T., ... Yoshida, H. (2005). T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Inflammatory Bowel Diseases, 11(12), 1044-1052. https://doi.org/10.1097/01.MIB.0000191611.05466.1f

T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. / Honda, Kuniomi; Nakamura, Kazuhiko; Matsui, Noriaki; Takahashi, Makoto; Kitamura, Yousuke; Mizutani, Takahiro; Harada, Naohiko; Nawata, Hajime; Hamano, Shinjiro; Yoshida, Hiroki.

:: Inflammatory Bowel Diseases, 巻 11, 番号 12, 01.12.2005, p. 1044-1052.

研究成果: ジャーナルへの寄稿記事

Honda, K, Nakamura, K, Matsui, N, Takahashi, M, Kitamura, Y, Mizutani, T, Harada, N, Nawata, H, Hamano, S & Yoshida, H 2005, 'T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis', Inflammatory Bowel Diseases, 巻. 11, 番号 12, pp. 1044-1052. https://doi.org/10.1097/01.MIB.0000191611.05466.1f
Honda, Kuniomi ; Nakamura, Kazuhiko ; Matsui, Noriaki ; Takahashi, Makoto ; Kitamura, Yousuke ; Mizutani, Takahiro ; Harada, Naohiko ; Nawata, Hajime ; Hamano, Shinjiro ; Yoshida, Hiroki. / T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. :: Inflammatory Bowel Diseases. 2005 ; 巻 11, 番号 12. pp. 1044-1052.
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abstract = "Background: WSX-1, a component of the interleukin (IL)-27 receptor, is a novel class I cytokine receptor with homology to the IL-12 receptor β2 chain. Initially, WSX-1 signaling was reported to play an important role in the promotion of T helper-1 responses, but recent reports have revealed an anti-inflammatory property in WSX-1 signaling. In the present study, we investigated the role of IL-27/WSX-1 signaling in a murine colitis model, dextran sulfate sodium (DSS) colitis, by using WSX-1 knockout (KO) mice. Methods: First, we observed whether WSX-1 KO mice developed colitis spontaneously. Second, we induced DSS colitis in WSX-1 KO and wild-type (WT) mice. Results: WSX-1 KO mice were observed not to develop colitis spontaneously. The severity of DSS colitis was decreased in WSX-1 KO mice in comparison with WT mice in association with a reduced production of interferon-γ, IL-6, and tumor necrosis factor-α by lamina propria mononuclear cells from WSX-1 KO mice and the absence of T-bet expression in the colon from WSX-1 KO mice. Conclusions: This study revealed the inflammatory property of IL-27/WSX-1 signaling in intestinal inflammation. As a result, IL-27/WSX-1 signal pathway may thus be a promising candidate for the therapeutic intervention of human inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.",
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AU - Honda, Kuniomi

AU - Nakamura, Kazuhiko

AU - Matsui, Noriaki

AU - Takahashi, Makoto

AU - Kitamura, Yousuke

AU - Mizutani, Takahiro

AU - Harada, Naohiko

AU - Nawata, Hajime

AU - Hamano, Shinjiro

AU - Yoshida, Hiroki

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N2 - Background: WSX-1, a component of the interleukin (IL)-27 receptor, is a novel class I cytokine receptor with homology to the IL-12 receptor β2 chain. Initially, WSX-1 signaling was reported to play an important role in the promotion of T helper-1 responses, but recent reports have revealed an anti-inflammatory property in WSX-1 signaling. In the present study, we investigated the role of IL-27/WSX-1 signaling in a murine colitis model, dextran sulfate sodium (DSS) colitis, by using WSX-1 knockout (KO) mice. Methods: First, we observed whether WSX-1 KO mice developed colitis spontaneously. Second, we induced DSS colitis in WSX-1 KO and wild-type (WT) mice. Results: WSX-1 KO mice were observed not to develop colitis spontaneously. The severity of DSS colitis was decreased in WSX-1 KO mice in comparison with WT mice in association with a reduced production of interferon-γ, IL-6, and tumor necrosis factor-α by lamina propria mononuclear cells from WSX-1 KO mice and the absence of T-bet expression in the colon from WSX-1 KO mice. Conclusions: This study revealed the inflammatory property of IL-27/WSX-1 signaling in intestinal inflammation. As a result, IL-27/WSX-1 signal pathway may thus be a promising candidate for the therapeutic intervention of human inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.

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