T helper subsets in Sjögren's syndrome and IgG4-related dacryoadenitis and sialoadenitis

A critical review

Masafumi Moriyama, Akihiko Tanaka, takashi maehara, Sachiko Furukawa, Hitoshi Nakashima, Seiji Nakamura

研究成果: ジャーナルへの寄稿評論記事

39 引用 (Scopus)

抄録

IgG4-related disease (IgG4-RD) is a systemic disease characterized by the elevation of serum IgG4 and infiltration of IgG4-positive plasma cells in multiple target organs, including the pancreas, kidney, biliary tract and salivary glands. In contrast, Mikulicz's disease (MD) has been considered a subtype of Sjögren's syndrome (SS) based on histopathological similarities. However, it is now recognized that MD is an IgG4-RD distinguishable from SS and called as IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS). Regarding immunological aspects, it is generally accepted that CD4+ T helper (Th) cells play a crucial role in the pathogenesis of SS. Since it is well known that IgG4 is induced by Th2 cytokines such as interleukin (IL)-4 and IL-13, IgG4-DS is speculated to be a unique inflammatory disorder characterized by Th2 immune reactions. However, the involvement of Th cells in the pathogenesis of IgG4-DS remains to be clarified. Exploring the role of Th cell subsets in IgG4-DS is a highly promising field of investigation. In this review, we focus on the selective localization and respective functions of Th cell subsets and discuss the differences between SS and IgG4-DS to clarify the pathogenic mechanisms of these diseases.

元の言語英語
ページ(範囲)81-88
ページ数8
ジャーナルJournal of Autoimmunity
51
DOI
出版物ステータス出版済み - 1 1 2014

Fingerprint

Dacryocystitis
Sialadenitis
Immunoglobulin G
Mikulicz' Disease
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
Interleukin-13
Biliary Tract
Plasma Cells
Salivary Glands
Interleukin-4
Pancreas

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

これを引用

T helper subsets in Sjögren's syndrome and IgG4-related dacryoadenitis and sialoadenitis : A critical review. / Moriyama, Masafumi; Tanaka, Akihiko; maehara, takashi; Furukawa, Sachiko; Nakashima, Hitoshi; Nakamura, Seiji.

:: Journal of Autoimmunity, 巻 51, 01.01.2014, p. 81-88.

研究成果: ジャーナルへの寄稿評論記事

@article{6d901bc9447f4a579d025792f0987f39,
title = "T helper subsets in Sj{\"o}gren's syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review",
abstract = "IgG4-related disease (IgG4-RD) is a systemic disease characterized by the elevation of serum IgG4 and infiltration of IgG4-positive plasma cells in multiple target organs, including the pancreas, kidney, biliary tract and salivary glands. In contrast, Mikulicz's disease (MD) has been considered a subtype of Sj{\"o}gren's syndrome (SS) based on histopathological similarities. However, it is now recognized that MD is an IgG4-RD distinguishable from SS and called as IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS). Regarding immunological aspects, it is generally accepted that CD4+ T helper (Th) cells play a crucial role in the pathogenesis of SS. Since it is well known that IgG4 is induced by Th2 cytokines such as interleukin (IL)-4 and IL-13, IgG4-DS is speculated to be a unique inflammatory disorder characterized by Th2 immune reactions. However, the involvement of Th cells in the pathogenesis of IgG4-DS remains to be clarified. Exploring the role of Th cell subsets in IgG4-DS is a highly promising field of investigation. In this review, we focus on the selective localization and respective functions of Th cell subsets and discuss the differences between SS and IgG4-DS to clarify the pathogenic mechanisms of these diseases.",
author = "Masafumi Moriyama and Akihiko Tanaka and takashi maehara and Sachiko Furukawa and Hitoshi Nakashima and Seiji Nakamura",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.jaut.2013.07.007",
language = "English",
volume = "51",
pages = "81--88",
journal = "Journal of Autoimmunity",
issn = "0896-8411",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - T helper subsets in Sjögren's syndrome and IgG4-related dacryoadenitis and sialoadenitis

T2 - A critical review

AU - Moriyama, Masafumi

AU - Tanaka, Akihiko

AU - maehara, takashi

AU - Furukawa, Sachiko

AU - Nakashima, Hitoshi

AU - Nakamura, Seiji

PY - 2014/1/1

Y1 - 2014/1/1

N2 - IgG4-related disease (IgG4-RD) is a systemic disease characterized by the elevation of serum IgG4 and infiltration of IgG4-positive plasma cells in multiple target organs, including the pancreas, kidney, biliary tract and salivary glands. In contrast, Mikulicz's disease (MD) has been considered a subtype of Sjögren's syndrome (SS) based on histopathological similarities. However, it is now recognized that MD is an IgG4-RD distinguishable from SS and called as IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS). Regarding immunological aspects, it is generally accepted that CD4+ T helper (Th) cells play a crucial role in the pathogenesis of SS. Since it is well known that IgG4 is induced by Th2 cytokines such as interleukin (IL)-4 and IL-13, IgG4-DS is speculated to be a unique inflammatory disorder characterized by Th2 immune reactions. However, the involvement of Th cells in the pathogenesis of IgG4-DS remains to be clarified. Exploring the role of Th cell subsets in IgG4-DS is a highly promising field of investigation. In this review, we focus on the selective localization and respective functions of Th cell subsets and discuss the differences between SS and IgG4-DS to clarify the pathogenic mechanisms of these diseases.

AB - IgG4-related disease (IgG4-RD) is a systemic disease characterized by the elevation of serum IgG4 and infiltration of IgG4-positive plasma cells in multiple target organs, including the pancreas, kidney, biliary tract and salivary glands. In contrast, Mikulicz's disease (MD) has been considered a subtype of Sjögren's syndrome (SS) based on histopathological similarities. However, it is now recognized that MD is an IgG4-RD distinguishable from SS and called as IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS). Regarding immunological aspects, it is generally accepted that CD4+ T helper (Th) cells play a crucial role in the pathogenesis of SS. Since it is well known that IgG4 is induced by Th2 cytokines such as interleukin (IL)-4 and IL-13, IgG4-DS is speculated to be a unique inflammatory disorder characterized by Th2 immune reactions. However, the involvement of Th cells in the pathogenesis of IgG4-DS remains to be clarified. Exploring the role of Th cell subsets in IgG4-DS is a highly promising field of investigation. In this review, we focus on the selective localization and respective functions of Th cell subsets and discuss the differences between SS and IgG4-DS to clarify the pathogenic mechanisms of these diseases.

UR - http://www.scopus.com/inward/record.url?scp=84901263449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901263449&partnerID=8YFLogxK

U2 - 10.1016/j.jaut.2013.07.007

DO - 10.1016/j.jaut.2013.07.007

M3 - Review article

VL - 51

SP - 81

EP - 88

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

ER -