Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation

Daiki Funamoto, Daisuke Asai, Chan Woo Kim, Yuta Nakamura, Eun Kyung Lee, Takanobu Nobori, Takuro Niidome, Takeshi Mori, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues.

元の言語英語
ページ(範囲)474-476
ページ数3
ジャーナルChemistry Letters
44
発行部数4
DOI
出版物ステータス出版済み - 1 1 2015

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Protein Kinase C
Genes
Peptides
Phosphorylation
Substrates
Gene expression
Serine

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

これを引用

Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation. / Funamoto, Daiki; Asai, Daisuke; Kim, Chan Woo; Nakamura, Yuta; Lee, Eun Kyung; Nobori, Takanobu; Niidome, Takuro; Mori, Takeshi; Katayama, Yoshiki.

:: Chemistry Letters, 巻 44, 番号 4, 01.01.2015, p. 474-476.

研究成果: ジャーナルへの寄稿記事

Funamoto, D, Asai, D, Kim, CW, Nakamura, Y, Lee, EK, Nobori, T, Niidome, T, Mori, T & Katayama, Y 2015, 'Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation', Chemistry Letters, 巻. 44, 番号 4, pp. 474-476. https://doi.org/10.1246/cl.141121
Funamoto, Daiki ; Asai, Daisuke ; Kim, Chan Woo ; Nakamura, Yuta ; Lee, Eun Kyung ; Nobori, Takanobu ; Niidome, Takuro ; Mori, Takeshi ; Katayama, Yoshiki. / Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation. :: Chemistry Letters. 2015 ; 巻 44, 番号 4. pp. 474-476.
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