Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor

T. Murata, T. Ishibashi, H. Yoshikawa, A. Khalil, H. Inomata

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

The antiangiogenic effect of tecogalan sodium on corneal neovascularization was investigated. Tecogalan sodium, a sulfated polysaccharide peptidoglycan complex isolated from an Arthrobacter species, has been reported to inhibit angiogenesis induced by basic fibroblast growth factor (bFGF) as well as tumor angiogenesis related to Kaposi's sarcoma. Corneal neovascularization induced by bFGF was inhibited by tecogalan sodium in a dose-dependent manner. Since bFGF is known to have a promoting effect on corneal neovascularization, tecogalan sodium may be a possible therapeutic agent for corneal neovascularization, which can cause severe visual disturbances.

本文言語英語
ページ(範囲)330-334
ページ数5
ジャーナルOphthalmic Research
27
6
DOI
出版ステータス出版済み - 1 1 1995

All Science Journal Classification (ASJC) codes

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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