Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita, Go Nagamatsu, Shigeru Saito, Keiyo Takubo, Katsuhisa Horimoto, Toshio Suda

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.

元の言語英語
ページ(範囲)15776-15787
ページ数12
ジャーナルJournal of Biological Chemistry
289
発行部数22
DOI
出版物ステータス出版済み - 5 30 2014

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Telomerase
Chromosomes
Stem cells
Induced Pluripotent Stem Cells
Chromosome Aberrations
Growth
Cellular Reprogramming

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming. / Kinoshita, Taisuke; Nagamatsu, Go; Saito, Shigeru; Takubo, Keiyo; Horimoto, Katsuhisa; Suda, Toshio.

:: Journal of Biological Chemistry, 巻 289, 番号 22, 30.05.2014, p. 15776-15787.

研究成果: ジャーナルへの寄稿記事

Kinoshita, Taisuke ; Nagamatsu, Go ; Saito, Shigeru ; Takubo, Keiyo ; Horimoto, Katsuhisa ; Suda, Toshio. / Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming. :: Journal of Biological Chemistry. 2014 ; 巻 289, 番号 22. pp. 15776-15787.
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