Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.
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