Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

The telomere length and its distribution were compared between patients administered with and without hypnotics to see if regular administration of hypnotics is associated with their aging-related somatic telomere shortening. Male patients presented significant shortening of telomere length of circulating leukocytes in association with age (-41.9 bp/year, p = 0.045) in contrast with controls (-18.3 kb/year, p = 0.155). On the other hand, female patients presented no significant shortening of telomere length with aging (-16.4 bp/year, p = 0.372) in contrast with controls (-55.9 bp/year, p = 0.00005). These results suggested that regular administration of hypnotics is associated with aging progression in a gender-related manner. The administration of hypnotics could be an indicator as the somatic aging status and for the screening of background lifestyle-associated diseases promoting biological aging.

本文言語英語
ページ(範囲)278-283
ページ数6
ジャーナルCanadian journal of physiology and pharmacology
99
3
DOI
出版ステータス出版済み - 2021

All Science Journal Classification (ASJC) codes

  • 生理学
  • 薬理学
  • 生理学(医学)

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