Tempol intake improves inflammatory status in aged mice

Mayumi Yamato, Ayumi Ishimatsu, Yuuki Yamanaka, Takara Mine, Ken-Ichi Yamada

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Oxidative stress is associated with both healthy aging and age-related disease states. In connection with oxidative stress, immunity is also a major component as a result of the chronic, low-grade inflammation associated with the development of tissue aging. Here we show that long-term treatment with the antioxidant tempol extends life-span in mice. Tempol-treated mice exhibited a reduction in mortality at 20 months. Tempol drinking did not have any effect on body weight, amount of visceral adipose tissue, or plasma biochemical parameters in aged mice. Body temperature of aged control mice (which drank only water) was significantly lower than young mice, but this reduction of body temperature was partially restored in aged mice which drank tempol. Plasma thiobarbituric acid-reactive substances and C-reactive protein were significantly increased in the control aged mice compared with young mice, but levels of both were normalized by tempol drinking. One of the endogenous antioxidants, ascorbic acid, was significantly increased in the plasma of mice which consumed tempol. The proportion of CD4 lymphocytes in the blood of aged tempol-treated mice was partially increased in comparison to aged control mice. These results suggest that the reduction of mortality by tempol is due to amelioration of chronic inflammation and improved function of the immune system through antioxidant effects.

元の言語英語
ページ(範囲)11-14
ページ数4
ジャーナルJournal of Clinical Biochemistry and Nutrition
55
発行部数1
DOI
出版物ステータス出版済み - 1 1 2014

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Oxidative stress
Antioxidants
Plasmas
Aging of materials
Body Temperature
Tissue
Drinking
Oxidative Stress
Lymphocytes
Thiobarbituric Acid Reactive Substances
tempol
Immune system
Inflammation
C-Reactive Protein
Ascorbic Acid
Intra-Abdominal Fat
Mortality
Blood
Temperature
Immune System

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

これを引用

Tempol intake improves inflammatory status in aged mice. / Yamato, Mayumi; Ishimatsu, Ayumi; Yamanaka, Yuuki; Mine, Takara; Yamada, Ken-Ichi.

:: Journal of Clinical Biochemistry and Nutrition, 巻 55, 番号 1, 01.01.2014, p. 11-14.

研究成果: ジャーナルへの寄稿記事

Yamato, Mayumi ; Ishimatsu, Ayumi ; Yamanaka, Yuuki ; Mine, Takara ; Yamada, Ken-Ichi. / Tempol intake improves inflammatory status in aged mice. :: Journal of Clinical Biochemistry and Nutrition. 2014 ; 巻 55, 番号 1. pp. 11-14.
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