Ten years of experience with liver transplantation for familial amyloid polyneuropathy in Japan: Outcomes of living donor liver transplantations

Yo Ichi Takei, Shu Ichi Ikeda, Toshihiko Ikegami, Yasuhiko Hashikura, Shin Ichi Miyagawa, Yukio Ando, Hiroyuki Furukawa, Motohide Shimazu, Masaki Kitajima, Hideya Kamei, Yoshihiko Maehara, Rie Nakao, Katsuyoshi Hatakeyama, Masatoshi Makuuchi, Yuichi Matsui, Koji Umeshita

研究成果: Contribution to journalArticle

36 引用 (Scopus)

抜粋

Object: We summarize 10 years of experience with liver transplantation for FAP patients in Japan and review the current opinions regarding this treatment for FAP. Methods and patients: All basic report data on patients at the time of transplantation were registered with the Japanese Liver Transplantation Society (JLTS). Based on the JLST report data, more detailed information on FAP patients was requested from each center. Results: Living donor liver transplantation (LDLT) for FAP patients was first performed in Japan in 1993. LDLT has since been performed in 41 FAP patients, including nine cases of temporary auxiliary partial orthotopic liver transplantation (APOLT). Orthotopic liver transplantation (OLT) from cadaveric donors for FAP patients began in 1999, but only one FAP patient has subsequently undergone this procedure. Of these total of 43 FAP patients, 36 are currently alive: the one-year survival rate of patients after transplantation was 93%, and the five-year survival rate of these cases was 77%. Preoperative clinical severity and the nutritional status of patients are correlated with their outcome after liver transplantation. Domino (sequential) liver transplantation has been carried out in 20 domino recipients with end-stage liver diseases. Of the 20 domino recipients, 12 are currently alive. Conclusion: For FAP patients, these outcomes after the operation were very similar to those of OLT from cadaveric donors reported in other countries. Therefore, we concluded that for the treatment of FAP, LDLT from a living donor is equally effective as OLT from a cadaveric donor.

元の言語英語
ページ(範囲)1151-1156
ページ数6
ジャーナルInternal Medicine
44
発行部数11
DOI
出版物ステータス出版済み - 12 1 2005

All Science Journal Classification (ASJC) codes

  • Internal Medicine

フィンガープリント Ten years of experience with liver transplantation for familial amyloid polyneuropathy in Japan: Outcomes of living donor liver transplantations' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Takei, Y. I., Ikeda, S. I., Ikegami, T., Hashikura, Y., Miyagawa, S. I., Ando, Y., Furukawa, H., Shimazu, M., Kitajima, M., Kamei, H., Maehara, Y., Nakao, R., Hatakeyama, K., Makuuchi, M., Matsui, Y., & Umeshita, K. (2005). Ten years of experience with liver transplantation for familial amyloid polyneuropathy in Japan: Outcomes of living donor liver transplantations. Internal Medicine, 44(11), 1151-1156. https://doi.org/10.2169/internalmedicine.44.1151