Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

Minoru Omura, Miyuki Hirata, Akiyo Tanaka, Mangen Zhao, Yuji Makita, Naohide Inoue, Kaoru Gotoh, Noburu Ishinishi

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

抄録

The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.

元の言語英語
ページ(範囲)123-129
ページ数7
ジャーナルToxicology Letters
89
発行部数2
DOI
出版物ステータス出版済み - 12 16 1996

Fingerprint

Semiconductors
Arsenic
Cricetinae
Toxicity
Semiconductor materials
Gallium
Spermatids
Serum
Spermatozoa
indium arsenide
gallium arsenide
Rats
arsenic trioxide
Experiments

All Science Journal Classification (ASJC) codes

  • Toxicology

これを引用

Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters. / Omura, Minoru; Hirata, Miyuki; Tanaka, Akiyo; Zhao, Mangen; Makita, Yuji; Inoue, Naohide; Gotoh, Kaoru; Ishinishi, Noburu.

:: Toxicology Letters, 巻 89, 番号 2, 16.12.1996, p. 123-129.

研究成果: ジャーナルへの寄稿記事

Omura, Minoru ; Hirata, Miyuki ; Tanaka, Akiyo ; Zhao, Mangen ; Makita, Yuji ; Inoue, Naohide ; Gotoh, Kaoru ; Ishinishi, Noburu. / Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters. :: Toxicology Letters. 1996 ; 巻 89, 番号 2. pp. 123-129.
@article{6caf046797ab40fb86536afe2d2c021b,
title = "Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters",
abstract = "The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.",
author = "Minoru Omura and Miyuki Hirata and Akiyo Tanaka and Mangen Zhao and Yuji Makita and Naohide Inoue and Kaoru Gotoh and Noburu Ishinishi",
year = "1996",
month = "12",
day = "16",
doi = "10.1016/S0378-4274(96)03796-4",
language = "English",
volume = "89",
pages = "123--129",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

AU - Omura, Minoru

AU - Hirata, Miyuki

AU - Tanaka, Akiyo

AU - Zhao, Mangen

AU - Makita, Yuji

AU - Inoue, Naohide

AU - Gotoh, Kaoru

AU - Ishinishi, Noburu

PY - 1996/12/16

Y1 - 1996/12/16

N2 - The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.

AB - The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.

UR - http://www.scopus.com/inward/record.url?scp=0030590959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030590959&partnerID=8YFLogxK

U2 - 10.1016/S0378-4274(96)03796-4

DO - 10.1016/S0378-4274(96)03796-4

M3 - Article

C2 - 8960154

AN - SCOPUS:0030590959

VL - 89

SP - 123

EP - 129

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 2

ER -