Th0-like CD4+ T cells protect mice with murine retrovirus-induced immunodeficiency syndrome (MAIDS) against co-infection with Listeria monocytogenes

K. Hiromatsu, H. Nishimura, K. Kimura, Y. Aoki, J. Usami, N. Kobayashi, M. Makino, Y. Yoshikai

    研究成果: Contribution to journalArticle査読

    2 被引用数 (Scopus)

    抄録

    We examined the host defence mechanism against infection with Listeria monocytogenes, a facultative intracellular bacterium, in mice with murine acquired immunodeficiency syndrome (MAIDS) caused by LP-BM5 murine leukaemia virus (MuLv) infection. Although LP-BM5 MuLV infection in C57BL16 mice leads to a stage of immunodeficiency characterized by severe compromise of cell-mediated immunity, the mice with established MAIDS infected with LP-BM5 8 weeks previously, showed resistance to an intraperitoneal infection with Listeria monocytogenes. These MAIDS mice also showed resistance to a lethal dose of secondary listerial challenge, while the delayed-type hypersensitivity response to heat-killed Listeria (HKL) was severely impaired in MAIDS mice. The resistance of MAIDS mice to listerial infection was mediated by CD4+ αβ T cells but neither by γδ T cells nor natural killer (NK) cells. Interferon-γ (IFN-γ) and interleukin-10 (IL-10) were produced by CD4+ T cells from Listeria-infected MAIDS mice in response to the in vitro stimulation with HKL, whereas IFN-γ but not IL-10 were produced by those from Listeria-infected control mice. These results suggest that T-helper 0 (Th0)-like immune responses of CD4+ T cells occur and participate in host defence mechanisms against listerial infection in MAIDS mice.

    本文言語英語
    ページ(範囲)532-538
    ページ数7
    ジャーナルImmunology
    89
    4
    DOI
    出版ステータス出版済み - 1996

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    フィンガープリント 「Th0-like CD4<sup>+</sup> T cells protect mice with murine retrovirus-induced immunodeficiency syndrome (MAIDS) against co-infection with Listeria monocytogenes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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