Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus

Mitsuteru Akahoshi, Hitoshi Nakashima, Yosuke Tanaka, Tsutomu Kohsaka, Shuji Nagano, Eiichi Ohgami, Yojiro Arinobu, Kunihiro Yamaoka, Hiroaki Niiro, Michiya Shinozaki, Hideki Hirakata, Takahiko Horiuchi, Takeshi Otsuka, Yoshiyuki Niho

研究成果: ジャーナルへの寄稿記事

228 引用 (Scopus)

抄録

Objective. To analyze the Th1/Th2 balance of peripheral Th cells in patients with systemic lupus erythematosus (SLE). Methods. The Th1:Th2 ratio was analyzed in 3 groups: SLE without proteinuria (group I; n = 23), SLE with proteinuria (group II; n = 31), and normal controls (group III; n = 24). Group II patients who had undergone renal biopsy were classified into 3 subgroups based on their renal histopathologic findings. The intracellular cytokine detection method with flow cytometry was used to quantitate Th1 and Th2 cells. Results. There was no difference in the mean Th1:Th2 ratio between SLE patients (groups I and II) and healthy controls (group III). However, the mean value in group II was significantly higher than those in groups I and III. Moreover, within group II, the mean value in SLE patients who had diffuse proliferative lupus nephritis (World Health Organization class IV) was especially high. Conclusion. Although SLE has been considered to be a disease in which Th2 cells predominate, the Th1/Th2 balance of peripheral Th cells in SLE patients in the present study did not show a predominance of these cells. In contrast, among SLE patients with WHO class IV lupus nephritis, there was a strong predominance of Th1.

元の言語英語
ページ(範囲)1644-1648
ページ数5
ジャーナルArthritis and rheumatism
42
発行部数8
DOI
出版物ステータス出版済み - 8 1 1999

Fingerprint

Th1-Th2 Balance
Helper-Inducer T-Lymphocytes
Systemic Lupus Erythematosus
Th2 Cells
Lupus Nephritis
Proteinuria
Kidney
Control Groups
Th1 Cells
Flow Cytometry
Cytokines
Biopsy

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

これを引用

Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. / Akahoshi, Mitsuteru; Nakashima, Hitoshi; Tanaka, Yosuke; Kohsaka, Tsutomu; Nagano, Shuji; Ohgami, Eiichi; Arinobu, Yojiro; Yamaoka, Kunihiro; Niiro, Hiroaki; Shinozaki, Michiya; Hirakata, Hideki; Horiuchi, Takahiko; Otsuka, Takeshi; Niho, Yoshiyuki.

:: Arthritis and rheumatism, 巻 42, 番号 8, 01.08.1999, p. 1644-1648.

研究成果: ジャーナルへの寄稿記事

Akahoshi, M, Nakashima, H, Tanaka, Y, Kohsaka, T, Nagano, S, Ohgami, E, Arinobu, Y, Yamaoka, K, Niiro, H, Shinozaki, M, Hirakata, H, Horiuchi, T, Otsuka, T & Niho, Y 1999, 'Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus', Arthritis and rheumatism, 巻. 42, 番号 8, pp. 1644-1648. https://doi.org/10.1002/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L
Akahoshi, Mitsuteru ; Nakashima, Hitoshi ; Tanaka, Yosuke ; Kohsaka, Tsutomu ; Nagano, Shuji ; Ohgami, Eiichi ; Arinobu, Yojiro ; Yamaoka, Kunihiro ; Niiro, Hiroaki ; Shinozaki, Michiya ; Hirakata, Hideki ; Horiuchi, Takahiko ; Otsuka, Takeshi ; Niho, Yoshiyuki. / Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. :: Arthritis and rheumatism. 1999 ; 巻 42, 番号 8. pp. 1644-1648.
@article{92a33cb345764ae28ef0cd4f597c8911,
title = "Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus",
abstract = "Objective. To analyze the Th1/Th2 balance of peripheral Th cells in patients with systemic lupus erythematosus (SLE). Methods. The Th1:Th2 ratio was analyzed in 3 groups: SLE without proteinuria (group I; n = 23), SLE with proteinuria (group II; n = 31), and normal controls (group III; n = 24). Group II patients who had undergone renal biopsy were classified into 3 subgroups based on their renal histopathologic findings. The intracellular cytokine detection method with flow cytometry was used to quantitate Th1 and Th2 cells. Results. There was no difference in the mean Th1:Th2 ratio between SLE patients (groups I and II) and healthy controls (group III). However, the mean value in group II was significantly higher than those in groups I and III. Moreover, within group II, the mean value in SLE patients who had diffuse proliferative lupus nephritis (World Health Organization class IV) was especially high. Conclusion. Although SLE has been considered to be a disease in which Th2 cells predominate, the Th1/Th2 balance of peripheral Th cells in SLE patients in the present study did not show a predominance of these cells. In contrast, among SLE patients with WHO class IV lupus nephritis, there was a strong predominance of Th1.",
author = "Mitsuteru Akahoshi and Hitoshi Nakashima and Yosuke Tanaka and Tsutomu Kohsaka and Shuji Nagano and Eiichi Ohgami and Yojiro Arinobu and Kunihiro Yamaoka and Hiroaki Niiro and Michiya Shinozaki and Hideki Hirakata and Takahiko Horiuchi and Takeshi Otsuka and Yoshiyuki Niho",
year = "1999",
month = "8",
day = "1",
doi = "10.1002/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L",
language = "English",
volume = "42",
pages = "1644--1648",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

TY - JOUR

T1 - Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus

AU - Akahoshi, Mitsuteru

AU - Nakashima, Hitoshi

AU - Tanaka, Yosuke

AU - Kohsaka, Tsutomu

AU - Nagano, Shuji

AU - Ohgami, Eiichi

AU - Arinobu, Yojiro

AU - Yamaoka, Kunihiro

AU - Niiro, Hiroaki

AU - Shinozaki, Michiya

AU - Hirakata, Hideki

AU - Horiuchi, Takahiko

AU - Otsuka, Takeshi

AU - Niho, Yoshiyuki

PY - 1999/8/1

Y1 - 1999/8/1

N2 - Objective. To analyze the Th1/Th2 balance of peripheral Th cells in patients with systemic lupus erythematosus (SLE). Methods. The Th1:Th2 ratio was analyzed in 3 groups: SLE without proteinuria (group I; n = 23), SLE with proteinuria (group II; n = 31), and normal controls (group III; n = 24). Group II patients who had undergone renal biopsy were classified into 3 subgroups based on their renal histopathologic findings. The intracellular cytokine detection method with flow cytometry was used to quantitate Th1 and Th2 cells. Results. There was no difference in the mean Th1:Th2 ratio between SLE patients (groups I and II) and healthy controls (group III). However, the mean value in group II was significantly higher than those in groups I and III. Moreover, within group II, the mean value in SLE patients who had diffuse proliferative lupus nephritis (World Health Organization class IV) was especially high. Conclusion. Although SLE has been considered to be a disease in which Th2 cells predominate, the Th1/Th2 balance of peripheral Th cells in SLE patients in the present study did not show a predominance of these cells. In contrast, among SLE patients with WHO class IV lupus nephritis, there was a strong predominance of Th1.

AB - Objective. To analyze the Th1/Th2 balance of peripheral Th cells in patients with systemic lupus erythematosus (SLE). Methods. The Th1:Th2 ratio was analyzed in 3 groups: SLE without proteinuria (group I; n = 23), SLE with proteinuria (group II; n = 31), and normal controls (group III; n = 24). Group II patients who had undergone renal biopsy were classified into 3 subgroups based on their renal histopathologic findings. The intracellular cytokine detection method with flow cytometry was used to quantitate Th1 and Th2 cells. Results. There was no difference in the mean Th1:Th2 ratio between SLE patients (groups I and II) and healthy controls (group III). However, the mean value in group II was significantly higher than those in groups I and III. Moreover, within group II, the mean value in SLE patients who had diffuse proliferative lupus nephritis (World Health Organization class IV) was especially high. Conclusion. Although SLE has been considered to be a disease in which Th2 cells predominate, the Th1/Th2 balance of peripheral Th cells in SLE patients in the present study did not show a predominance of these cells. In contrast, among SLE patients with WHO class IV lupus nephritis, there was a strong predominance of Th1.

UR - http://www.scopus.com/inward/record.url?scp=0033509042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033509042&partnerID=8YFLogxK

U2 - 10.1002/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L

DO - 10.1002/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L

M3 - Article

C2 - 10446863

AN - SCOPUS:0033509042

VL - 42

SP - 1644

EP - 1648

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 8

ER -